Is Schitter on Single-molecule Dna Sequencing with Functionalized Carbon Nanotube Probes
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چکیده
A single molecule of DNA is denatured and immobilized on an atomically flat substrate, and a carbon nanotube force probe functionalized with a nucleotide is scanned along the molecule to detect locations of the probe nucleotide’s complement. Discussion is offered regarding the preparation of single-walled carbon nanotube AFM probes and their chemical attachment of DNA nucleotides. Additionally, a model of the oscillating cantilever under the influence of an arbitrary tip force is reviewed and it is shown that attractive forces are measured as a decrease in the cantilever phase, relative to its driving signal. Finally, singlestranded DNA of a known sequence is scanned with a thymine-functionalized carbon nanotube force probe. Copyright c ©IFAC 2006
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تاریخ انتشار 2006